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Presented by Ben Schmidt, Ph.D., Senior Staff Scientist
July 14, 2022 at 10:00 a.m. CST
X-ray photoelectron spectroscopy (XPS) is a commonly used surface analysis technique for elemental and chemical characterization of the top few nanometers of a material. However, analysis of some materials can be tricky when using the traditional monochromatic Al X-ray source due to effects of adventitious contamination, buried interfaces, or spectral overlaps. With the advent of lab-based hard X-ray spectrometers (HAXPES), higher energy X-ray probe beams allow the collection of photoelectron signals from deeper in the material, thereby minimizing these effects. Additionally, it is possible to perform ion beam sputter depth profiling while minimizing the effect of atomic mixing or chemical reduction often seen with an Al X-ray source.
In this webinar, Ben will discuss recent developments on the PHI Quantes Scanning XPS/HAXPES Microprobe instrument, which utilizes both Al Ka (1486.6 eV) and Cr Ka (5414.8 eV) X-ray sources for XPS and HAXPES analysis, respectively. Significant advances have been made in developing sensitivity factors for quantitative HAXPES analysis, as well as software improvements for data collection and processing. Several application areas will be highlighted to show the advantage of the Cr X-ray source in analysis of battery materials, microelectronics, carbon-containing materials, and perovskites.
In drug development many applications are found for lipid-based nanoparticles (LbNPs) as successful transporters for poorly water-soluble drugs and oligonucleotides in gene therapy.
At Physical Electronics, the innovation never stops. And as the sole supplier of PHI products in Canada, SRC can help you leverage PHI innovation to achieve your goals.
For today’s advanced materials
The PHI VersaProbe 4 is a highly versatile, multi-technique instrument with PHI’s patented, monochromatic, micro-focused, scanning X-ray source. The instrument offers true SEM-like ease of operation with superior micro-area spectroscopy and excellent large-area capabilities. The fully integrated multi-technique platform of the PHI VersaProbe 4 offers an array of optional excitation sources, sputter ion sources, and sample treatment and transfer capabilities. These features are essential in studying today’s advanced materials and supporting your material characterization.
The new PHI VersaProbe 4 has improved spectroscopic performance, new large area imaging and mapping capabilities, and environmentally friendly modern configuration with efficient power consumption, faster pump-down and ergonomic design.
The PHI VersaProbe 4 offers:
Intuitive sample navigation and confident analysis area identification
Optimized depth profiling
Superior micro-area analysis
Suite of specialized solutions for in-situ characterization of advanced materials
PHI—trusted by researchers the world over
Publishing recent discoveries in science and technology in peer-reviewed literature is a critical function of members of the research community. In 2021 over 4500 scholar publications, including peer-reviewed articles and book chapters, were published using PHI XPS instruments. On top of this there were more than 60 papers published in the high-impact journals (Nature and Science group). The new PHI VersaProbe 4 will reinforce the trust that researchers have in PHI instruments.
Contact
To learn more about the new PHI VersaProbe 4 or to request a quote, contact us at SRC. We’d be delighted to put PHI innovation to work for you.
Additive manufacturing (AM), also known as 3D printing, is a transformative/disruptive approach to industrial production in a broad range of fields that cost-effectively enables the creation of lighter, stronger, and more geometrically complex parts and systems. It is another technological advance made possible by the digitization of processes. AM uses data computer-aided-design (CAD) software or 3D object scanners to direct hardware to deposit material, layer upon layer, in precise geometric shapes. As its name implies, AM adds material to create an object. By contrast, when you create an object by traditional analog methods, it is often necessary to remove material through milling, machining, carving, shaping or other means.
The ability to design and print virtually any object shape using a diverse array of materials, such as metals, polymers, bioinks—and ceramics—has given rise to the use of AM in biomedicine in both research and clinical settings. The world of 3D ceramic printing has come a long way since the 1980s, when it was considered suitable only for the production of functional or aesthetic prototypes, and a more appropriate term for it at the time was “rapid prototyping.” This article reviews the additive manufacturing of ceramics in biomedicine, as well as the technology and products of a leading SRC supplier, 3DCeram.
The additive manufacturing of ceramics for biomedical applications allows for the creation of bone substitutes, custom implants and surgical tools. The exceptional biocompatibility, extremely regular porous structure, capacity for the formation of complex geometrical shapes and mechanical strength are the main qualities of these 3D bioceramics. 3Dbioceramics can also be produced cost-effectively and relatively quickly and, when incorporated into the human body, provide more safety and comfort for the patient and require less follow-up after surgery. Given these many attributes, the future of additive manufacturing of ceramics for biomedical applications is extremely bright and the market is expected to grow by leaps and bounds as healthcare systems seek to control spiralling patient care costs, and applications not previously considered advisable or possible continue to emerge.
The medical sector has always been interested in cutting-edge technologies, which is why 3DCeram began working with biomedical players in 2005. In subsequent years 3DCeram has focused on developing a mastery of the 3D printing ceramics process, 3D printers, ceramic materials and services encompassing maintenance and training. Today, the company is the undisputed global leader in the additive manufacturing of ceramics for biomedical applications.
3D Ceram leverages stereolithography (SLA) 3D printing technology to manufacture custom-made or small series bone substitutes and cranial or jawbone implants. The technology can be used to produce ceramic components layer by layer using a laser that polymerizes a paste composed of photosensitive resin and ceramic. The parts are then subjected to a heat treatment (debinding followed by sintering) that eliminates the resin and densifies the ceramic.
Custom-made HAP implant for the repair of large and complex craniofacial bone defects
With over a decade of medical 3D printing experience under its belt, 3DCeram produces a range of ceramic 3D printers and materials that are suitable for biomedical applications, including the accessible C100 EASY FAB system and the production-grade C3600 ULTIMATE. The company offers a number of materials that have been specifically formulated for biocompatibility and osteointegration, such as HAP (Hyd roxyapatite), TCP (Tricalcium Phosphate) and ATZ (Alumina Toughened Zirconia). 3DCeram’s products are suitable for many types of biomedical applications, from cranial and jawbone implants to dental devices.
Ceramaker 3600 ULTIMATE
In the biomedical sector, however, the ability to 3D print highly advanced or customized devices is not quite enough: all medical parts and products must undergo and meet stringent requirements. When it comes to the adoption of ceramic 3D printing in the medical sphere, certifications have not been a deal breaker, but they have created a bottleneck. CDCeram has pursued streamlining of the certification process for its biomedical customers through a new partnership with Gregory Nolens.
With a PhD in Biomedical Sciences and expertise in additive manufacturing and medical regulations, Gregory Nolens is uniquely equipped to help biomedical companies and players to not only implement ceramic 3D printing for medical device development and production, but to obtain the necessary certifications.
Contact
SRC is proud to represent 3DCeram in Canada and make available to our Canadian customers in the biomedical field the full range of 3DCeram products. Click here to contact SRC to learn more.
Biopharmaceuticals are large and complex molecular drugs that are mainly obtained from proteins and nucleic acids of living organisms, such as microorganisms and animal cells, also known as transgenic organisms. These drugs are obtained using biotechnology and have high-therapeutic value. Biopharmaceuticals are also known as biologics and biotech drugs and are usually administered by intravenous, subcutaneous, or intramuscular injections and are more efficient than the conventional small molecule drugs.
Biopharmaceuticals are an alternative to previously less effective and sometimes unsafe treatments and offer several benefits. Biopharmaceutical benefits include their highly effective and potent action, reduced side effects, capacity to be tailored according to the specific medical requirements of patients and potential to actually cure diseases at the root level. Biopharmaceuticals have reduced the number of deaths due to cancer and HIV/AIDS in the past decade and have changed the treatment of several chronic diseases, such as diabetes and cardiovascular diseases.
Some of the biopharmaceuticals include monoclonal antibodies, erythropoietin, growth hormones, recombinant proteins, recombinant human insulin, purified proteins, interferon, and vaccines. Recombinant human insulin was amongst the first substances to be approved for therapeutic purposes. Currently, there are nearly 300 biopharmaceutical products that have been approved and are available in the market.
Sphere Fluidics is a SRC supplier focused on developing technology that enables leading-edge research and accelerates biopharmaceutical discovery. They do this by providing novel single cell analysis systems for the rapid screening and characterisation of single cells. Their patented picodroplet technology is specifically designed to increase the likelihood of finding that rare molecule or cell that can lead to a life-changing medicine.
Sphere Fluidics has made a fast-track antibody discovery: a high-throughput method for identifying and isolating rare cells secreting antigen-specific antibodies. Antibody-derived biologics have become a major class of modern medicine, particularly in the fight against cancer and autoimmune diseases. Highly efficacious immunoglobulin-based drugs have been developed naturally via the antibody-producing B cells of the mammalian immune system, although finding rare cells with the right characteristics has always been challenging.
The Cyto-Mine® Single Cell Analysis System is Sphere Fluidics’ flagship product—the first integrated, benchtop system to automatically analyse, sort and dispense millions of individual cells in just a single day. Cyto-Mine® technology finds and isolates cells secreting antigen-specific antibodies from complex cell populations.
Join us for a 1 hour seminar about Wettability and Adhesion, where we will go through how to utilize contact angles for wettability measurements and evaluation of adhesion. We will also address the theory behind them and emphasize strategies how to apply these measurements to real, non-ideal surfaces which may be heterogeneous in both surface chemistry and surface roughness.
Wettability and adhesion are key parameters in numerous industries such as coatings, biotechnology and electronics. The seminar will include lecture and a demonstration of how to account for the surface roughness and wettability determination for advanced research.
In collaboration with Biolin Scientific AB, we warmly welcome you to take part in the upcoming Biolin Scientific Attension Online Seminar 2021, Practical applications on surface tension & contact angle. The seminar will be hosted in two sessions on the 30th of November 2021 & participation is 100% free! Sign up today to hear what the subject matter experts have to say about their latest research.
Check out some of our guest speakers!
Iria Torres
Researcher
Sanofi – Frankfurt
Katja Klinar
Researcher at University of Ljubljana,
Slovenia
Jakub Sandak
Researcher at
InnoRenew CoE & University of Primorska
Andrew White
Scientist
at BASF Agricultural Solutions
Timo Kotilahti
Research
engineer in Aalto University
Dr. Ankit D.Kanthe
Analytical Scientist at
Bristol Myers Squibb
Morning session
Time
Presentation
Speaker and title
09:00 – 09:10 am
Welcome/Introduction
Biolin Scientific
09:10 – 09:30 am
Surface tension evaluation of small volume samples through the pendant drop method
Iria Torres Teran, Sanofi
09:30 – 09:50 am
Surface tension measurements of METNINTM lignin fractions
Petri Ihalainen, Metgen
09:50 – 10:10 am
Using Theta Flex for bioproducts research at Aalto University
Timo Kotilahti, Aalto University
10:10 – 10:30 am
TBD
10:30 – 11:00 am
Improve Accuracy and Repeatability of Contact Angle Measurements with the Theta Flow
Susanna Laurén, Biolin Scientific
11:00 – 11:15 am
Break
11:15 – 11:35 am
Assessing surface properties of heterogeneous and porous biological origin building materials, such as wood
Jakub Sandak, Innorenew
11:35 – 11:55 am
Optimizing characterization of wetting behaviour of milk powders by contact angle measurements
Riitta Partanen, Valio
11:55 – 12:15 pm
Wettability in gluing and finishing processes of lignocellulosic materials
Tomasz Krystofiak, Poznań University of Life Sciences
12:15 – 12:45 pm
Importance of goniometry study in membrane science
Joanna Kujawa, Nicolaus Copernicus University
12:45 – 1:30 pm
Q&A
All times are in CET (Central European Time)
Evening session
Time
Presentation
Speaker and title
4:30 – 4:40 pm
Welcome/Introduction
4:40 – 5:00 pm
Digital microfluidics: Electrowetting
Katja Klinar, University of Ljubljana
5:00 – 5:20 pm
TBA
5:20 – 5:50 pm
Dynamics of mixed antibody-excipient adsorption at an air/water interface
Ankit Kanthe, Bristol Myers Squibb
5:50 – 6:20 pm
Live demo Theta Flow
6:20 – 6:35 pm
Break
6:35 – 7:05 pm
Probing Lipid Monolayers with Pendant Drops: From Surface Pressure Isotherms to Interfacial Rheology
Andrew White, University of California, Riverside
7:05 – 7:25 pm
Characterization and analysis of hydrophobicity, interfacial tension and contact angle of acetyl TAG used for various food applications.
Advances in battery technologies are at the forefront of a sustainable global economy, and refinements that further reduce the cost and optimize the performance of batteries are essential. SRC, through our technology partner suppliers, provides laboratories pursuing these refinements with pivotal technologies for battery R&D and QA/QC. Please keep reading to learn more about instrumentation from SRC and our innovative suppliers.
Thermo Scientifichelps innovate in dry or low-solvent electrode manufacturing. The twin-screw extruder compounds
anode material with minimized solvent addition. The highly viscous pastes are processed into pellets which are easily
transported and stored without aging. The pellets can later be coated onto collector foil and calendared in one step.
Electrolytes are a key component in battery performance. Oxford Instruments’ benchtop NMR technology can quickly and easily distinguish between the diffusion behavior of different electrolyte solvents and help characterize important parameters such as conductivity and ion transference. For battery R&D, the Oxford Instruments X-Pulse Broadband Benchtop NMR Spectrometer provides critical data for electrolyte design.
X-ray Photoelectron Spectroscopy(XPS) from Physical Electronics (PHI) is an important tool for
battery material research and development. XPS can provide insights into battery performance at realistic operating conditions, and help determine the precise location of interfaces between battery components. Electronic band structure of organic and inorganic materials can also be characterized using XPS.
The Flex AFM Atomic Force Microscope from Nanosurfcan be used to characterize the surface topography of battery materials and components. The AFM tip can also be made electrically active and
used as a probe for nanoscale conductive/ resistive pathways. Measurements can be done within an
electrochemical cell to passively observe changes due to charge/discharge events.
Raman Imaging Systems from WITec provide comprehensive battery material characterization.
Raman imaging can highlight the distribution of electrolyte and electrode materials and investigate
their crystallinity.
Battery particle charge (zeta potential) can affect slurry production and stability. The Brookhaven Instruments NanoBrook Omni provides fast, routine measurement of submicron particle size and zeta
potential. This technology will help you understand sedimentation and agglomeration.
AmbiValue’s EyeTech™ Particle Size and Shape Analyzer provides fast and accurate particle size and
shape analysis. Particle morphology is key for achieving optimal battery performance because particle shape affects slurry rheology, electrode coating density, porosity and uniformity.
Lithium-ion batteries are the main energy storage technology for mobile devices such as smartphones and laptops. The wettability of different parts of Li-ion batteries has become one of the key issues both in terms of manufacturing as well as for the performance and safety of batteries.
Welcome to our Attension Seminar-30th of November, 2021!
We are happy to invite you to an exciting seminar online where researchers from both academy and industry come together to share their insight and experience in practical applications for surface tension and contact angle. Have a look at the agenda for our two sessions below and sign up today!
Morning session
Time
Presentation
Speaker and title
09:00 – 09:10 am
Welcome/Introduction
Biolin Scientific
09:10 – 09:30 am
Surface tension evaluation of small volume samples through the pendant drop method
Iria Torres Teran, Sanofi
09:30 – 09:50 am
Surface tension measurements of METNINTM lignin fractions
Petri Ihalainen, Metgen
09:50 – 10:10 am
Using Theta Flex for bioproducts research at Aalto University
Timo Kotilahti, Aalto University
10:10 – 10:30 am
TBD
10:30 – 11:00 am
Improve Accuracy and Repeatability of Contact Angle Measurements with the Theta Flow
Susanna Laurén, Biolin Scientific
11:00 – 11:15 am
Break
11:15 – 11:35 am
Assessing surface properties of heterogeneous and porous biological origin building materials, such as wood
Jakub Sandak, Innorenew
11:35 – 11:55 am
Optimizing characterization of wetting behaviour of milk powders by contact angle measurements
Riitta Partanen, Valio
11:55 – 12:15 pm
Wettability in gluing and finishing processes of lignocellulosic materials
Tomasz Krystofiak, Poznań University of Life Sciences
12:15 – 12:45 pm
Importance of goniometry study in membrane science
Joanna Kujawa, Nicolaus Copernicus University
12:45 – 1:30 pm
Q&A
All times are in CET (Central European Time)
Evening session
Time
Presentation
Speaker and title
4:30 – 4:40 pm
Welcome/Introduction
4:40 – 5:00 pm
Digital microfluidics: Electrowetting
Katja Klinar, University of Ljubljana
5:00 – 5:20 pm
TBA
5:20 – 5:50 pm
Dynamics of mixed antibody-excipient adsorption at an air/water interface
Ankit Kanthe, Bristol Myers Squibb
5:50 – 6:20 pm
Live demo Theta Flow
6:20 – 6:35 pm
Break
6:35 – 7:05 pm
Probing Lipid Monolayers with Pendant Drops: From Surface Pressure Isotherms to Interfacial Rheology
Andrew White, University of California, Riverside
7:05 – 7:25 pm
Characterization and analysis of hydrophobicity, interfacial tension and contact angle of acetyl TAG used for various food applications.
Integrate, Customize and Make Accessible: 3D Bioprinting is Medicine’s Next Frontier
The growing push for 3-D tissue models is limited by challenges in automated handling, processing, and scalability of the technology to various types of materials and high-throughput applications. To meet these challenges, 4D bioprinting and human-cell derived ECM bioinks can allow researchers to biologically mimic the formation of complex, heterogeneous 3-D structures and to scale the technology to high-throughput and clinically translatable applications. This webinar will discuss the latest megatrends behind bioprinting developments as well as scientific and medical applications developed for tissue engineering, regenerative medicine, preclinical screening and testing, veterinary medicine, as well as personalized drug and food development. Some key topics to be discussed include:
Key advantages of 3D bioprinting over other techniques
Alterations in cellular physiology of cells in 3D vs. 2D
Megatrends behind bioprinting’s importance in biomedicine
Introduction of biomedical applications of bioprinting across various disciplines
ROKIT Healthcare’s work in clinical translation of bioprinting in the operating room
Built-in cell incubator, diverse material use, and high-throughput capabilities of all-in-one bioprinting platforms
The seminar reinforces the significance of bioprinting advancements in the age of Industry 4.0 – as a movement aligned with global megatrends in healthcare toward personalized medicine, computer-aided production of biological processes, and autologous regenerative therapy.
Guest Speaker:
• Da-Yae Lee Senior Bio-Consultant & Project Leader
When:
Thursday 8 September 9-10 am – Conference (in-person & virtual) 10:00 am- 12:00 pm – Workshop (limited spaces,
priority to 1st registered)
Where:
Conference room at the Centre
Québecois d’Innovation en
Biotechnologie (CQIB),
500 Bd Cartier O, Laval, QC H7V 5B7
Integrate, Customize and Make Accessible: 3D Bioprinting is Medicine’s Next Frontier
The growing push for 3-D tissue models is limited by challenges in automated handling, processing, and scalability of the technology to various types of materials and high-throughput applications. To meet these challenges, 4D bioprinting and human-cell derived ECM bioinks can allow researchers to biologically mimic the formation of complex, heterogeneous 3-D structures and to scale the technology to high-throughput and clinically translatable applications. This webinar will discuss the latest megatrends behind bioprinting developments as well as scientific and medical applications developed for tissue engineering, regenerative medicine, preclinical screening and testing, veterinary medicine, as well as personalized drug and food development. Some key topics to be discussed include:
Key advantages of 3D bioprinting over other techniques
Alterations in cellular physiology of cells in 3D vs. 2D
Megatrends behind bioprinting’s importance in biomedicine
Introduction of biomedical applications of bioprinting across various disciplines
ROKIT Healthcare’s work in clinical translation of bioprinting in the operating room
Built-in cell incubator, diverse material use, and high-throughput capabilities of all-in-one bioprinting platforms
The seminar reinforces the significance of bioprinting advancements in the age of Industry 4.0 – as a movement aligned with global megatrends in healthcare toward personalized medicine, computer-aided production of biological processes, and autologous regenerative therapy.
Guest Speaker:
• Da-Yae Lee Senior Bio-Consultant & Project Leader
When:
Thursday 9 September 9-11 am – Conference (in-person & virtual) 1:45-5:00 pm – Personalized meetings
Where:
Conference: l’hôpital Saint François d’Assise A0-202 (Amphithéâtre Roger-Breault)
Meetings: Univeristé Laval Pavillon Adrien-Pouliot, Room: PLT-3510
The world of 3D Ceramic Printing has come a long way since the 1980s when it was considered suitable only for the production of functional or aesthetic prototypes, and a more appropriate term for it at the time was “rapid prototyping”. Today, the the precision, repeatability, and material range of 3D printing have increased to the point that some 3D printing processes are considered viable as an industrial-production technology, whereby the term “additive manufacturing” can be used synonymously with 3D printing.
Applications of 3D ceramic printing
In this article we are going to look at 3D printing—or additive manufacturing if you will—using ceramic materials for the following applications:
1) Production of ceramic foundry cores;
2) Optimization of optical instrumentation.
Types of ceramics used in 3D printing
Before we get too far into the weeds with the two applications highlighted above, let’s briefly have a look at the types of ceramics used in 3D printing. Generally speaking, the qualities of ceramic materials are: high strength, high dimensional stability (low coefficient of thermal expansion), low density, high resistance to abrasion and corrosion, and exceptional chemical stability. There is a variety of ceramic materials used in 3D printing, which are categorized into:
Non-oxide ceramics: silicon nitride and aluminum nitride.
3D Ceram Sinto, a leader in the world of 3D ceramic printing, offers a full range of ready-to-use ceramic pastes for use with their CERAMAKER printers. Naturally, they advise their customers on the critical issue of the ceramic paste best suited to the application at hand, but can also create ceramic paste formulations according to specifications provided by their customers.
3D Ceram ceramic paste
3D printing of ceramic foundry cores
Foundry cores are integral to the production of turbine blades for aviation, aero-derivative and land-based gas turbines. Up to now manufacturing cores has been a time- and labour intensive process. Today, in an effort to lower fuel consumption, improve turbine efficiency and decrease engine emissions, core designs are becoming increasingly complex. Making a complex, porous ceramic foundry core using conventional manufacturing processes involves making the core in several pieces and then assembling them manually. The likelihood of a problem occurring in this process is considerable, resulting in wasted time and materials—and excessively high costs.
Some of the constraints applied to core production:
Dimensional accuracy +/- 0.1 mm
Structural strength
Surface roughness
Material porosity
Additive manufacturing brings a new dimension to conventional industrial processes, allowing all of these elements to be controlled. In addition to saving time and materials and increasing productivity in the production of ceramic foundry cores, the technology delivers the following benefits:
Design flexibility
Possibility of more core complexity
Quick creation of new designs
Better responsiveness and productivity
Increased profitability
Maintenance of core strength
3D printing of optical instruments
3D printing is one of the key technologies for devising innovative solutions contributing to the optimization of optical instruments, such as a plane mirror for a front-end laser engine (galvo-mirror for high-energy laser application). 3D printing can greatly enhance the design and manufacturing of the optical substrate of such an instrument.
Two types of mirror
The use of additive manufacturing for the production of optical instruments has the following benefits:
Parts are lighter because they feature more complex designs that incorporate holes and semi-closed structures
Lead time is reduced as there is no need to manufacture and then lighten by machining a first draft
Less ceramic is used, which reduces costs
New, more complex and disruptive designs are possible
New functions such as internal channels, electrical tracks and feedthroughs can be incorporated.
As a result of new additive manufacturing technology, optical substrates and mirrors can now be more compact, thus allowing for additional functions while still keeping volume and mass low.
Industrial 3D ceramic printers
We’ve touched on the ceramic pastes used in 3D ceramic printing and must do likewise with 3D ceramic printers. The number of ceramic 3D printers on the market has increased steadily in recent years and many industrial solutions are now available. Indeed, more manufacturers are offering professional solutions, capable of designing high-quality parts with increasing speed.
3DCeram Sinto is undoubtedly one of the historical players in ceramic additive manufacturing and has developed a professional range based on a stereolithography process. 3D Ceram Sinto’s CERAMAKER 3D printer family has the widest range and most
practical printing platforms of any company in the market, ranging from the C100 (100 x 100 x 150 mm) to the C3600 (300 x 300 x 100 mm). Taking shrinkage into account, you can produce parts with dimensions up to Ø500 mm with the CERAMAKER C3600.
