Manufacturing

Overcome drug formulation challenges

Pharmaceutical manufacturers are using conical and twin-screw extruders to mix drug molecules with bioactive polymers in situations where drug ingredients are poorly soluble or unstable during processing. Extruders are also useful in preparing enteric dosages, sustained release dosages, in taste-masking, and to create forms such as films.

Gain the advantages of a continuous process

Continuous granulation offers a more efficient and cost-effective route for producing tablets and capsules, particularly when developing new formulations where scale-up is difficult due to the narrow optimal working points found in batch devices such as mixers, agitators and choppers.

• Requires only 3g (4mL) of material for compounding
• Small footprint, fanless design with separate, touch-screen control for operation in fume cabinet or glovebox applications
• Removable and exchangeable product contact parts for quick and easy cleaning
• IP 54 for protection against dust and water allows the Pharma mini HME to be spray-washed
• Useable as small-scale production unit for throughputs of 100g/h
• Touch screen control with user levels and password protection
• Data logging software as option to record temperatures, torque, and screw speed
• Optional batch conversion kit to use the Pharma mini HME as small batch mixer
• Complementary workflow solution when coupled with the Thermo Scientific™ HAAKE™ MiniJet injection molder

Lithography systems can accommodate substrates of arbitrary shapes with lateral dimensions of up to 1400 x 1400 mm²