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Introducing the Thermo Scientific Pharma mini HME Micro Compounder
The Thermo Scientific™ Pharma mini HME is a GMP compliant conical micro compounder for Hot Melt Extrusion in research and development in the pharmaceutical industry. When developing new drugs, shortening time-to-market and reducing waste of expensive API’s and overall development costs provide a distinct competitive advantage. Hence, quick and early assessment of new API/excipient formulations is critical. Hot melt extrusion and continuous processing can lead to speedier formulation development and cost efficient production. The Thermo Scientific Pharma mini HME allows users to identify the right drug candidates for hot melt extrusion by compounding as little as three grams of material.
Key Features
With the Pharma mini HME, we offer a micro twin-screw compounder which requires as little as three grams of total material to identify the right drug candidates for hot melt extrusion. The compounder with conical co- or counter-rotating screws is designed to minimize waste and reduce downtime necessary for cleaning.
Requires only 3g (4mL) of material for compounding
Small footprint, fanless design with separate, touch-screen control for operation in fume cabinet or glovebox applications
Removable and exchangeable product contact parts for quick and easy cleaning
IP 54 for protection against dust and water allows the Pharma mini HME to be spray-washed
Useable as small-scale production unit for throughputs of 100g/h
Touch screen control with user levels and password protection
Data logging software as option to record temperatures, torque, and screw speed
Optional batch conversion kit to use the Pharma mini HME as small batch mixer
Complementary workflow solution when coupled with the Thermo Scientific™ HAAKE™ MiniJet injection molder
Key Benefits
Materials:
Pharmaceutical ingredients (API’s)
Excipients
Medical polymers
Drug delivery systems
Soft gels
Applications:
Hot melt extrusion
Medical devices
Implants
Controlled drug release
Handling and processing of highly potent API’s in a glovebox
A small footprint reduces clean room volumes, and lower ingredient consumption reduces handling and operator exposure.
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Spectra Research Corporation (SRC) offers a range of innovative high-quality scientific products and laboratory services to industrial and scientific markets throughout Canada.
Specifications
Motor power
400W
Speed range
10…360 min-1
Max. torque
5 Nm / shaft
Power supply
230V ± 10%, 50/60 Hz
115V ± 10%, 60 Hz
Temperature
max. 280 °C with 2 set points
Heating time
<10 min
Volume
3 g (4 ml)
Screw design
Co- or counter-rotating, pharma
grade stainless steel 1.4112 (440B)
Barrel
High performance / pharma grade
stainless steel M340
Catalog number
Unit Size
Barrel
Description
Max. Screw Speed
Price (CAD)
553-6050
–
High performance / pharma grade stainless steel M340
2-in-1 process design – quickly disassemble parts for easy cleaning and process switching from HME to TSG.
Simple continuous process integration – plug-and-play functionality with upstream and downstream process equipment (e.g., feeders, chill rolls, pelletizers, dryers, etc) simplifies production line design.
Less optimization time, cost and effort – extruder process parameters are scaleable to larger Thermo Scientific extruders due to geometric similarity with minimal use of expensive ingredients.
Testing individual and combined influences of additives (stabilizer, lubricant) and functional additives (anti-oxidation, UV-stabilizers, pigments and fillers)
The Energy 11 Twin-Screw Extruder can be set up for a wide range of applications encountered in current battery R&D. The fully ported, horizontally split barrel allows for flexible feeding of solid and liquid ingredients. Interchangeable die designs adapt to a range of materials from dry granules, polymeric solid-state electrolytes, and electrode films to wet slurries. Eight precisely controlled temperature zones along the barrel ensure flexibility in processing.
Pharmaceutical manufacturers are using conical and twin-screw extruders to mix drug molecules with bioactive polymers in situations where drug ingredients are poorly soluble or unstable during processing. Extruders are also useful in preparing enteric dosages, sustained release dosages, in taste-masking, and to create forms such as films.
