Genizer

High Shear Liquid Homogenizer for lipid nanoparticle preparation (up to 60,000 psi)

UltraGenizer is a laboratory ultra high pressure processing device. It is an electrically-driven and bench-top high shear homogenizer, which requires no compressed air or hydraulic oil to achieve maximum 4,200 bar (60,000 psi) operating pressure.

• Efficient – More uniform particle size distribution
• Flexible – Flow range: 12~35 L/hr, suitable for medium-scale production Continuous
• Stable – Working pressure up to 60,000 psi ensures stable homogenization
• Intelligent – PLC real-time monitoring of flow, temperature, and pressure
• Safe – Hygienic stainless steel and pharmaceutical-grade surface treatment
• Economical – Affordable price for genuine microfluidics technology
• Quiet – Operating noise below 60 dB does not affect personnel

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• Portable hand driven homogenizer for concept testing up to 30,000 psi.
• Low-cost high pressure homogenizer
• Portable design delivers the light weight and small dimensions
• Convenient hand operation without the need for compressed gas
• A better choice for small-scale formulation screening
• An alternative to the high pressure homogenizers driven by compressed air

Y-Type Diamond Interaction Chamber (DIXC) is used to produce uniform nanoparticles in a high pressure homogenizer. The fixed geometry within the Y-Type DIXC is intended to create a uniform processing profile so that all materials will be processed with equal disruptive forces. Single-slotted interaction chambers have a single microchannel and are ideal choices for small batch research, while the multi-slotted interaction chamber comprises multiple microchannels in parallel, which can be used at industrial scales, by increasing the flow rate through the DIXC but with equal processing forces.

Z-Type Diamond Interaction Chamber (DIXC) is used to produce uniform nanoparticles in a high-pressure homogenizer. The fixed geometry within the Z-Type DIXC is intended to create a uniform processing profile so that all materials will be processed with equal disruptive forces. Single-slotted interaction chambers have a single microchannel and are ideal choices for small batch research, while the multi-slotted interaction chamber comprises multiple microchannels in parallel, which can be used at industrial scales, by increasing the flow rate through the DIXC but with equal processing forces.

Diamond Interaction Chamber (DIXC) is used to produce uniform nanoparticles in a high-pressure homogenizer. The fixed geometry within the DIXC is intended to create a uniform processing profile so that all materials will be processed with equal disruptive forces. Single-slotted interaction chambers have a single microchannel and are ideal choices for small batch research, while the multi-slotted interaction chamber comprises multiple microchannels in parallel, which can be used at industrial scales, by increasing the flow rate through the DIXC but with equal processing forces.

Mixing Diamond Interaction Chamber (DIXC) is a chamber specially designed for mixing and homogenizing the sample fluids from two or more inlet ports. The multiple streams will mix homogenously at the diamond mixing chamber where the fluids pass through the fixed micro-channels and experience high shears and strong impacts.

The HandExtruder is a manually powered extruder designed for the formulation of 0.25mL-2.0mL liposome and lipopolyplex with small samples. The sample is passed back through the membrane by being pushed back and forth between two syringes. Homogeneous samples can be produced quickly and easily in minutes; typically 5-10 passes are sufficient to produce a sample with uniform liposome size. The HandExtruder offers minimal dead-volume, is easy to clean and is suitable for sterilization. Temperature control is available

Genizer Multi Online Liposome Extruders System can be connected with a sanitary pump or high pressure homogenizer and are temperature-controlled, from pilot testing to manufacturing production of pharmaceutical liposomes such as anti-cancer drugs. Homogenous samples can be produced quickly and easily in minutes; typically 3-5 passes are sufficient to produce a sample with uniform liposome size. The Genizer Multi Online Liposome Extruders System is designed to generate homogeneous unilamellar liposomes and lipopolyplex. Extrusion is a one-step procedure that produces liposomes by forcing lipid suspensions of drug, protein or gene through track-etched filters of defined pore size. The Multi Online Extruders System offers minimal dead volume, is easy to clean, suitable for sterilization and compliant with FDA and GMP sanitary standards in pharmaceuticals.

The Genizer Jacketed Liposome Extruders is compressed air-driven and temperature-controlled, from testing to manufacturing production of liposome and lipopolyplex, for drug and gene delivery. Homogeneous samples can be produced quickly and easily in minutes; typically 5-10 passes are sufficient to produce a sample with uniform liposome size. Genizer Jacketed Liposome Extruders are designed to generate homogeneous unilamellar liposomes and Lipopolyplex. Extrusion is a one-step procedure that produces liposomes by forcing lipid suspensions of drug, protein or gene through track-etched filters of defined pore size. The process is relatively gentle, exposing the formulation to moderate pressures up to 500 psi at controlled temperatures. The Genizer Jacketed Extruder offers virtually no dead-volume, is easy to clean, suitable for sterilization and in compliance with FDA and GMP sanitary standards in pharmaceuticals.