Sphere Fluidics

Cyto-Mine® – Antibody discovery and cell line development workflows streamlined like never before

• Targeted Discovery – .Rapidly identify and isolate your rare cells of interest.
• Monoclonality Assurance – Extensive proof of monoclonality for cell line development.
• Significantly Reduce Timelines and Costs – Tens of millions of cells in pools or hundreds of thousands individually are screened in a single day.
• Flexibility – Flexible assay design allows quantitative measurement of antibody secretion.
• Sterility – The entire process is automated, sterile and Animal Origin Free. The Benchtop system is compatible for use in Class II biosafety cabinets.

Cyto-Mine® – Antibody discovery and cell line development workflows streamlined like never before

• Targeted Discovery – .Rapidly identify and isolate your rare cells of interest.
• Monoclonality Assurance – Extensive proof of monoclonality for cell line development.
• Significantly Reduce Timelines and Costs – Tens of millions of cells in pools or hundreds of thousands individually are screened in a single day.
• Flexibility – Flexible assay design allows quantitative measurement of antibody secretion.
• Sterility – The entire process is automated, sterile and Animal Origin Free. The Benchtop system is compatible for use in Class II biosafety cabinets.

• Semi-automated – Modular system for analysis of single cells or biomolecules in picodroplets.
• High-throughput – High-speed processing, detection and sorting of picodroplets (up to 12,000 per minute).
• Measure secreted proteins – Enables sensitive detection of secreted proteins (e.g. cytokines, antibodies, enzymes).
• Choice of parameters – User-defined microfluidic flow rates, picodroplet size, gating settings.
• Multiple detection modes – Range of optical detection methods (fluorescence, luminescence & scatter).

• Optimized for use with Pico-Surf™ and our other specialist chemicals
• Compatible with our range of Pico-Gen™ microfluidic biochips.
• Especially formulated to be biocompatible and stable.
• High purity and long shelf life (up to one year).
• Animal Origin Free.
• Experienced scientific and application support available.
• Volume – 100 ml, 250 ml, 500 ml

Pico-Break™ is used to used to gently reduce the stability of picodroplets in order to release cellular or molecular contents into an aqueous medium for subsequent processing.

Pico-Glide™ is a coating agent designed for users who manufacture their own microfluidic biochips using plasma etched glass or PDMS.

– A reliable, high-performing surfactant for droplet microfluidics

• Biocompatibility– designed for generating aqueous picodroplets in oil
• Highest droplet stability– shown by assessment of picodroplet fusion, interfacial tension and critical micelle concentration
• Stability at high temperature– demonstrated by the low level of picodroplet fusion
• Low voltage for droplet sorting– purity and quality of the surfactants enables a more efficient sorting process
• Excellent batch-to-batch reproducibility– all products undergo rigorous QC and QA testing to ensure batch consistency
• Unique and patented molecular surfactant structure – patent freedom to operate in a wide range of application areas.
• Specialist expertise and support– our team brings extensive experience and support to guide your applications