Technologies

The HandExtruder is a manually powered extruder designed for the formulation of 0.25mL-2.0mL liposome and lipopolyplex with small samples. The sample is passed back through the membrane by being pushed back and forth between two syringes. Homogeneous samples can be produced quickly and easily in minutes; typically 5-10 passes are sufficient to produce a sample with uniform liposome size. The HandExtruder offers minimal dead-volume, is easy to clean and is suitable for sterilization. Temperature control is available

Genizer Multi Online Liposome Extruders System can be connected with a sanitary pump or high pressure homogenizer and are temperature-controlled, from pilot testing to manufacturing production of pharmaceutical liposomes such as anti-cancer drugs. Homogenous samples can be produced quickly and easily in minutes; typically 3-5 passes are sufficient to produce a sample with uniform liposome size. The Genizer Multi Online Liposome Extruders System is designed to generate homogeneous unilamellar liposomes and lipopolyplex. Extrusion is a one-step procedure that produces liposomes by forcing lipid suspensions of drug, protein or gene through track-etched filters of defined pore size. The Multi Online Extruders System offers minimal dead volume, is easy to clean, suitable for sterilization and compliant with FDA and GMP sanitary standards in pharmaceuticals.

The Genizer Jacketed Liposome Extruders is compressed air-driven and temperature-controlled, from testing to manufacturing production of liposome and lipopolyplex, for drug and gene delivery. Homogeneous samples can be produced quickly and easily in minutes; typically 5-10 passes are sufficient to produce a sample with uniform liposome size. Genizer Jacketed Liposome Extruders are designed to generate homogeneous unilamellar liposomes and Lipopolyplex. Extrusion is a one-step procedure that produces liposomes by forcing lipid suspensions of drug, protein or gene through track-etched filters of defined pore size. The process is relatively gentle, exposing the formulation to moderate pressures up to 500 psi at controlled temperatures. The Genizer Jacketed Extruder offers virtually no dead-volume, is easy to clean, suitable for sterilization and in compliance with FDA and GMP sanitary standards in pharmaceuticals.

Process Chillers Fluid Chillers for Low Temperature Cooling

Thermonics specializes in the design and manufacture of low temperature standard and custom fluid chillers for challenging applications. The W-40-1100 FluidChill™ system delivers high reliability and precision temperature control.

• Touch-screen controller provides precise temperature control with data logging, graphing, performance monitoring, and fault alarms
• Magnetically coupled pump to match wetted materials
• Compatible with multiple heat transfer fluids
• Communications options for remote control and reading chiller parameters

Process Chillers Fluid Chillers for Low Temperature Cooling

Thermonics specializes in the design and manufacture of low temperature standard and custom fluid chillers for challenging applications. The W-60-4700 FluidChill™ system delivers high reliability and precision temperature control.

• Touch-screen controller provides precise temperature control with data logging, graphing, performance monitoring, and fault alarms
• Magnetically coupled pump to match wetted materials
• Compatible with multiple heat transfer fluids
• Communications options for remote control and reading chiller parameters

The chiller controller provides precision temperature control with touch-screen operation, easy-to-read information, remote operation, and data logging. Developed by our in-house engineering team, this controller provides flexible setup and customization not readily achievable with PLCs.

• Displays critical parameters such as fluid supply and return temperature and pressure (based on chiller options selected)
• Alarms for out-of-temperature range, low process flow, low reservoir level, and more
• Built-in diagnostics – valve counts, ambient temp, equipment runtimes
• Displays temperature graphs
• Communicates via Ethernet, USB, HTML Web server, RS-232 (optional)
• Logs system data and performance
• CE and RoHs compliant

• Low control over the production process
• Interruption of the production flow every time conditions are changed
• Need for laboratory analysis
• Impossibility to carry out Continuous Manufacturing (24-hour)
• Long time for analysis (10 min – hours)
• Variations in product quality due to absence of full process control
• Reduction in analysis time >90%
• Better process understanding promoting innovation
• New possibilities to study particle size dynamics in real time
• Reduction of production time with 1-3 days per batch
• Significant reduction in batch rejection saving € 0.2- 2M per manufacturing eve

• Form deviation from 3D CAD models
• Calibration of surface texture measuring instruments
• Sub-micron height repeatability over entire extended area
• One shot height measurement up to 40 mm without Z scanning
• Bi-telecentric lenses with very low field distortion providing accurate metrology

Simply powerful

• Sample Navigation – An overview tool helps the user to inspect the sample during measurement preparation
• Auto 3D Function – the SensoSCAN software automatically
• Analysis & Reporting – It is also possible to create analysis templates
• Automating procedures module – Automated measurements are obtained using the Recipes tool
• Extended measurements module – Allows the user to easily define the measurement layout on the surface by means of the overview image

• Complete accessibility
• Cover a wide range of scales
• Maximum versatility
• A complete 3D measurement
• Measure angles greater than 90º
• Measurements without limitation
• Accurate and reliable

• Flexible. Powerful.
• 3D auto function
• Live image options
• Designed to be
• simple and easy to use
• It is time to play. . .
• uses premium CF60-2 Nikon objectives
• Obtain a clear and well-structured report
• Adaptable column – Flexible options are designed to avoid restrictions between samples with differing heights.

• Integrable metrology solutions
• Robust, rugged and reliable
• Versatile or fast
• Maximum measurement versatility
• Unprecedented high speed
• Compact, light and orientation agnostic

• Powerful Analysis Software
• 3D exportable in multiple formats
• Simple yet powerful, designed for you
• Smart calculations tool for key parameters
• The most perceptive visualization of your topographies
• Customizable reports for more flexible results presentations

• Easy to use
• Completely modularly adaptable to customer requirements
• Two levels (standard and premium) and several modules are available
• Digital Surf, is an extremely powerful tool for analysis nad reporting

Rapid Quality Control

• Guide tool for the QC manager
• Extremely fast
• Command line available
• Parameter statistical analysis module
• Exportable reports in multiple formats
• Automatized custom analysis solutions

The DriveAFM, Nanosurf‘s new flagship instrument, utilizes the latest technology to deliver stable, high-end performance. It was designed to fulfill the needs of top notch research, today and in the future.

• CleanDrive: stable excitation in air and liquid
• Ultra low noise: below 15 fm/√Hz
• Direct drive: high-resolution imaging and large scan area
• Fully motorized system: full control via software